Novak Djokovic sailed into the US Open third round Wednesday in his quest for a 24th Grand Slam triumph as Iga Swiatek and Coco Gauff stayed on a quarterfinal collision course in New York.

Order of Play | Watch Live on DStv

Djokovic climbed through the gears against 76th-ranked Bernabe Zapata Miralles, winning 13 of the last 15 games to ease through 6-4, 6-1, 6-1 in two hours on Arthur Ashe Stadium court.

Next up for the Serbian star is compatriot and 32nd seed Laslo Djere, with Djokovic keeping up his record of always reaching at least the last 32 in New York.

"At 36 years of age, after 20 years of coming to New York, I still have the hunger to play my best tennis on this court," said Djokovic, a three-time US Open champion.

"I have the experience and understanding of what needs to be done in the important moments. Preserving the energy and focusing on the present moment."

Defending champion and world No 1 Swiatek swept past Australia's Daria Saville 6-3, 6-4.

The Pole is bidding to become the first woman to successfully defend her US Open crown since Serena Williams won a hat-trick of titles from 2012-2014.

"It wasn't easy but I'm happy I tried to play my game and play aggressively with a lot of intensity and I'm just happy to be in the third round," said Swiatek, aiming for her fifth Grand Slam triumph.

Swiatek will now play Slovenia's Kaja Juvan on Friday for a place in the last 16.

Gauff, 19, brushed aside 16-year-old Mirra Andreeva, the youngest player in the draw, 6-3, 6-2 to continue her strong run on hard courts this summer after titles in Washington and Cincinnati.

The sixth seed, viewed as one of the favourites in New York, takes on Belgium's Elise Mertens for a place in the last 16 after getting the better of Andreeva for the second time in three Grand Slams.

"I just learned to be aggressive, because if you give her something she is going to take advantage," said Gauff, who overcame Andreeva in three sets at Roland Garros in June.

"She has a great future in front of her - I think she is going to be back on this stage many more times."

Mertens, the 32nd seed, battled back from the brink by saving two match points in the second-set tie-break to knock off the dangerous Collins, last year's Australian Open runner-up.

The Belgian, who had the support of three-time US Open winner Kim Clijsters in her box, advanced 3-6, 7-6 (9/7), 6-1 and now awaits Gauff.

ZHANG MAKES HISTORY

Zhang Zhizhen sent fifth seed Casper Ruud crashing out of the US Open on Wednesday, creating tennis history by becoming the first man from China to beat a top-five player.

The 26-year-old from Shanghai – ranked 67th in the world – produced the match of his life to defeat last year's US Open finalist 6-4, 5-7, 6-2, 0-6, 6-2 in 3hr 19min.

Zhang's victory was the first time any male Chinese player has beaten a player ranked in the world's top five.

Zhang will face Australia's Rinky Hijikata in the third round on Friday, bidding to reach the last 16 of a Grand Slam for the first time.

Tempers flared after Ruud had levelled the match at two sets apiece with a 6-0 fourth set.

Zhang left the court for several minutes to take a toilet break and change clothes in a move that clearly disrupted Ruud's momentum.

The Norwegian was broken immediately in the first game of the final set, and a frustrated Ruud complained angrily at the chair umpire, accusing him of failing to enforce time limits.

"Why don't you do anything?" Ruud yelled at the umpire. "You follow the rules clearly some times then other times you don't give a shit. Why don't you do anything?"

With Ruud unravelling, Zhang rammed home his advantage. He broke again in the fifth game to take a 4-1 lead and then held for a 5-1 lead.

Ruud held serve to close the gap to 5-2, but Zhang would not be denied, producing a superb backhand volley on match point to seal victory.

FRITZ EAZES PAST VARRILAS

Ninth seed Taylor Fritz marched into the third round of the US Open with a 6-1 6-2 6-2 win over Juan Pablo Varillas on Wednesday to match his best result at his home Grand Slam.

Fritz, who is bidding to become the first US man to win a major in two decades, has shown his best form on hard courts this season and secured his 33rd victory on the surface to go level with Daniil Medvedev at the top.

"It's great to just have these matches. They're also good confidence builders," said Fritz, who has dropped only 10 games in two matches so far.

"I haven't had the easiest time this year getting through these early rounds so it feels really good to come on court and take care of business like I did in the last two matches."

Fritz set the tone at Louis Armstrong Stadium by breaking Peruvian Varillas in the second game and grabbed another break late in the opening set to close it out in only 26 minutes.

Varillas struggled to deal with the power and accuracy that Fritz produced but the 27-year-old did not help his own cause with a flurry of errors - 29 in the match overall - and allowed his opponent to double his lead comfortably.

Fritz encountered a little more resistance in the third set but got his nose in front and held firm for a win that set up a third-round encounter with Czech qualifier Jakub Mensik.

WOZNIACKI'S US OPEN RETURN CONTINUES WITH KVITOVA UPSET

Caroline Wozniacki claimed the biggest win of her comeback and a spot in the third round of the US Open on Wednesday as the Dane's Grand Slam adventure continued with an 7-5 7-6(5) upset of 11th seed Petra Kvitova.

Twice a finalist at Flushing Meadows, Wozniacki was back on the stage she has graced so many times against a familiar foe in front of an adoring crowd under the Arthur Ashe Stadium lights.

Having retired in 2020 to raise a family and playing in just her third event since returning to action Wozniacki turned back the clock to come out on top in the battle of 33-year-old Grand Slam champions.

The last time Wozniacki beat a top 20 ranked opponent was at the 2018 WTA Finals when she took down then world No 5 Kvitova.

Five years later, their 15th meeting ended with the same outcome.

The match did not start well for Wozniacki as Kvitova broke her to open the contest. But the Dane hit back immediately with a break of her own and then clinched the first set with another break.

Kvitova was never going to outwork the Dane, who endeared herself to New Yorkers by returning to the city to run the marathon, but the Czech had other weapons including a willingness to go for the big shot.

Wozniacki showed that she still possesses some firepower and used it to blast back-to-back aces to secure a decisive break to seal the first set.

The play remained just as tight in the second with Kvitova serving to stay in the contest at 5-5, fighting off two match points to send the set to a tie-break.

But Wozniacki would not be denied, clinching the tie-break 7-5 when the Czech's desperate forehand sailed long.

TSITSIPAS DUMPED OUT

Stefanos Tsitsipas' miserable US Open run continued as he crashed out to 21-year-old Swiss qualifier Dominic Stricker in five sets.

Tsitsipas served for the match at 5-3 in the fourth set but the 128th-ranked Stricker rallied to prevail 7-5, 6-7 (2/7), 6-7 (5/7), 7-6 (8/6), 6-3 in just over four hours.

"I don't know how. I did it somehow. Actually a bit speechless but it's a great day," said Stricker, who had won just one Grand Slam match before this week.

Greece's Tsitsipas, the seventh seed and a two-time Grand Slam finalist, has never progressed beyond round three in six visits to New York.

Czech 10th seed Karolina Muchova, this year's French Open finalist, sailed past Magdalena Frech in straight sets.

Olympic gold medallist Belinda Bencic ended the run of British qualifier Lily Miyazaki 6-3, 6-3, but Brazilian 19th seed Beatriz Haddad Maia was dumped out by Taylor Townsend 7-6 (7/1), 7-5.

Fifth seed Casper Ruud, runner-up at three of the past six majors including last year's US Open, takes on China's Zhang Zhizhen in his second round match on Wednesday.

Elena Rybakina, the women's fourth seed, plays Australian Ajla Tomljanovic in the night session on Louis Armstrong, while old rivals Petra Kvitova and Caroline Wozniacki also meet under the lights.